Selective, non-covalent conjugation of synthetic peptides with recombinant proteins mediated by host–guest chemistry

Abstract

The combination of potent chemical moieties with biologically active proteins is key to some of today's most innovative therapeutic drugs. In order to obviate any chemical modification of the proteins, we present a novel and powerful strategy for the selective conjugation of recombinant protein domains with synthetically derived peptides via a cucurbit[8]uril host–guest chemistry approach.