Structure of a novel 13 nm dodecahedral nanocage assembled from a redesigned bacterial microcompartment shell protein

J. Jorda; D. J. Leibly; M. C. Thompson; T. O. Yeates

doi:10.1039/C6CC00851H

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Structure of a novel 13 nm dodecahedral nanocage assembled from a redesigned bacterial microcompartment shell protein†

J. Jorda,^a D. J. Leibly,^ab M. C. Thompson^b and T. O. Yeates*^ab

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* Corresponding authors

^a UCLA-DOE Institute for Genomics and Proteomics, University of California, Los Angeles, CA 90095, USA
E-mail: yeates@mbi.ucla.edu

^b Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095, USA

Abstract

We report the crystal structure of a novel 60-subunit dodecahedral cage that results from self-assembly of a re-engineered version of a natural protein (PduA) from the Pdu microcompartment shell. Biophysical data illustrate the dependence of assembly on solution conditions, opening up new applications in microcompartment studies and nanotechnology.

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Article information

DOI: https://doi.org/10.1039/C6CC00851H
Article type: Communication
Submitted: 27 Jan 2016
Accepted: 09 Mar 2016
First published: 09 Mar 2016

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Chem. Commun., 2016,52, 5041-5044

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Structure of a novel 13 nm dodecahedral nanocage assembled from a redesigned bacterial microcompartment shell protein

J. Jorda, D. J. Leibly, M. C. Thompson and T. O. Yeates, Chem. Commun., 2016, 52, 5041 DOI: 10.1039/C6CC00851H

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Chemical Communications

Structure of a novel 13 nm dodecahedral nanocage assembled from a redesigned bacterial microcompartment shell protein†

Abstract

Supplementary files

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Structure of a novel 13 nm dodecahedral nanocage assembled from a redesigned bacterial microcompartment shell protein

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