Issue 31, 2016
From the journal:

Chemical Communications

Copper-catalyzed oxidative coupling between quinazoline 3-oxides and unactivated aldehydes: an efficient approach to functionalized quinazolines†

Liwen Fan,a   Tao Wang,*ab   Ying Tian,a   Fei Xiong,a   Simei Wu,a   Qingjin Lianga  and  Junfeng Zhao*ab  

* Corresponding authors

a College of Chemistry & Chemical Engineering, Jiangxi Normal University, 99, Ziyang Road, Nanchang, Jiangxi, P. R. China
E-mail: wangtao@jxnu.edu.cn, zhaojf@jxnu.edu.cn

b National Research Center for Carbohydrate Synthesis, Key Laboratory of Chemical Biology, Jiangxi Province, China

Abstract

A copper-catalyzed oxidative coupling between quinazoline 3-oxides and unactivated aldehydes was described. The reaction worked well for both aliphatic and aromatic aldehydes and produced not only the direct oxidative coupling ketones but also cyclic hydroxamic esters derived from quinazolines.

Graphical abstract: Copper-catalyzed oxidative coupling between quinazoline 3-oxides and unactivated aldehydes: an efficient approach to functionalized quinazolines

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Article information

DOI
https://doi.org/10.1039/C6CC00946H
Article type
Communication
Submitted
02 Feb 2016
Accepted
29 Feb 2016
First published
07 Mar 2016

Chem. Commun., 2016,52, 5375-5378

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Copper-catalyzed oxidative coupling between quinazoline 3-oxides and unactivated aldehydes: an efficient approach to functionalized quinazolines

L. Fan, T. Wang, Y. Tian, F. Xiong, S. Wu, Q. Liang and J. Zhao, Chem. Commun., 2016, 52, 5375 DOI: 10.1039/C6CC00946H

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