Issue 41, 2016
From the journal:

Chemical Communications

Transition metal-free generation of the acceptor/acceptor-carbene via α-elimination: synthesis of fluoroacetyl cyclopropanes†

Yongdong Wang,a   Jing Han,b   Jie Chenb  and  Weiguo Cao*abcde  

* Corresponding authors

a School of Environmental and Chemical Engineering, Shanghai University, 99 Shang Da Road, Shanghai 200444, P. R. China
E-mail: wgcao@staff.shu.edu.cn
Fax: +86-21-6613 4856

b Department of Chemistry, Innovative Drug Research Center, Shanghai University, 99 Shang Da Road, Shanghai 200444, P. R. China

c Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, P. R. China

d State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, P. R. China

e Key Laboratory of Synthetic Organic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, P. R. China

Abstract

An efficient transition metal-free approach for the generation of acceptor/acceptor-carbene followed by trapping with alkenes to provide fluoroacetyl cyclopropanes has been described. The resulting cyclopropanes could be further converted into the fluoromethyl dihydrofurans or fluorodihydropyrroles through ring-expansion processes.

Graphical abstract: Transition metal-free generation of the acceptor/acceptor-carbene via α-elimination: synthesis of fluoroacetyl cyclopropanes

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Article information

DOI
https://doi.org/10.1039/C6CC01576J
Article type
Communication
Submitted
22 Feb 2016
Accepted
21 Apr 2016
First published
22 Apr 2016

Chem. Commun., 2016,52, 6817-6820

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Transition metal-free generation of the acceptor/acceptor-carbene via α-elimination: synthesis of fluoroacetyl cyclopropanes

Y. Wang, J. Han, J. Chen and W. Cao, Chem. Commun., 2016, 52, 6817 DOI: 10.1039/C6CC01576J

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