Issue 54, 2016
From the journal:

Chemical Communications

Sequence-specific detection of cytosine methylation in DNA via the FRET mechanism between upconversion nanoparticles and gold nanorods†

Mingmin Wu,a   Xiaoyong Wang,*b   Kun Wanga  and  Zijian Guo*a  

* Corresponding authors

a State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, P. R. China
E-mail: zguo@nju.edu.cn

b State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, P. R. China
E-mail: boxwxy@nju.edu.cn

Abstract

A general detection method for DNA methylation is developed based on the FRET mechanism between upconversion nanoparticles and gold nanorods, which can recognize the cytosine methylation in a known DNA strand at a concentration as low as 7 pM.

Graphical abstract: Sequence-specific detection of cytosine methylation in DNA via the FRET mechanism between upconversion nanoparticles and gold nanorods

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Article information

DOI
https://doi.org/10.1039/C6CC02674E
Article type
Communication
Submitted
30 Mar 2016
Accepted
07 Jun 2016
First published
07 Jun 2016

Chem. Commun., 2016,52, 8377-8380

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Sequence-specific detection of cytosine methylation in DNA via the FRET mechanism between upconversion nanoparticles and gold nanorods

M. Wu, X. Wang, K. Wang and Z. Guo, Chem. Commun., 2016, 52, 8377 DOI: 10.1039/C6CC02674E

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