Issue 44, 2016

Rod-shaped and fluorine-substituted hydroxyapatite free of molecular immunopotentiators stimulates anti-cancer immunity in vivo

Abstract

Herein, rod-shaped and fluorine-substituted hydroxyapatite nanoparticles (FHA) were synthesized using a facile hydrothermal method. The rod-shaped FHA significantly increased the cellular uptake of a model antigen by bone marrow dentritic cells in vitro, improved antigen presentation in vivo, stimulated immune-related cytokine secretion in vitro and ex vivo, and enhanced the anti-cancer immunity in vivo.

Graphical abstract: Rod-shaped and fluorine-substituted hydroxyapatite free of molecular immunopotentiators stimulates anti-cancer immunity in vivo

Supplementary files

Article information

Article type
Communication
Submitted
06 Apr 2016
Accepted
19 Apr 2016
First published
21 Apr 2016
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2016,52, 7078-7081

Rod-shaped and fluorine-substituted hydroxyapatite free of molecular immunopotentiators stimulates anti-cancer immunity in vivo

X. Wang, X. Li, A. Ito, Y. Watanabe and N. M. Tsuji, Chem. Commun., 2016, 52, 7078 DOI: 10.1039/C6CC02848A

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