Issue 59, 2016
From the journal:

Chemical Communications

Paramagnetic lanthanide chelates for multicontrast MRI†

Nevenka Cakić,a   Tanja Savić,a   Janice Stricker-Shaver,a   Vincent Truffault,b   Carlos Platas-Iglesias,c   Christian Mirkes,d   Rolf Pohmann,d   Klaus Scheffler*de  and  Goran Angelovski*a  

* Corresponding authors

a MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics, 72076 Tübingen, Germany
E-mail: goran.angelovski@tuebingen.mpg.de

b Max Planck Institute for Developmental Biology, 72076 Tübingen, Germany

c Centro de Investigaciones Científicas Avanzadas (CICA) and Departamento de Química Fundamental, Universidade da Coruña, 15008 A Coruña, Spain

d High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, 72076 Tübingen, Germany
E-mail: klaus.scheffler@tuebingen.mpg.de

e Department for Biomedical Magnetic Resonance, University of Tübingen, 72076 Tübingen, Germany

Abstract

The preparation of a paramagnetic chelator that serves as a platform for multicontrast MRI, and can be utilized either as a T1-weighted, paraCEST or 19F MRI contrast agent is reported. Its europium(III) complex exhibits an extremely slow water exchange rate which is optimal for the use in CEST MRI. The potential of this platform was demonstrated through a series of MRI studies on tube phantoms and animals.

Graphical abstract: Paramagnetic lanthanide chelates for multicontrast MRI

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C6CC04011J
Article type
Communication
Submitted
12 May 2016
Accepted
02 Jun 2016
First published
02 Jun 2016
This article is Open Access
Creative Commons BY license

Chem. Commun., 2016,52, 9224-9227

Permissions

Request permissions

Paramagnetic lanthanide chelates for multicontrast MRI

N. Cakić, T. Savić, J. Stricker-Shaver, V. Truffault, C. Platas-Iglesias, C. Mirkes, R. Pohmann, K. Scheffler and G. Angelovski, Chem. Commun., 2016, 52, 9224 DOI: 10.1039/C6CC04011J

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements