A new and efficient method focusing on probe-modified peptides was developed to identify the target protein and modification site of a hit compound or a drug. This method exhibited high click conjugation efficiency and few false-positive results. The modification site further facilitated target validation, biological mechanism study and new indications exploration.
H. Sun, Y. Ren, W. Hou, L. Li, F. Zeng, S. Li, Y. Ma, X. Liu, S. Chen and Z. Zhang, Chem. Commun., 2016, 52, 10225 DOI: 10.1039/C6CC04030F
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