We report herein a proline-derived transannular N-cap as a helix nucleating template in diverse bio-related peptide sequences via macrolactamization on resin. This approach takes advantage of synergistic stabilization effects of both N-capping properties of proline and substitution of a main chain hydrogen bond with a covalent bond.
Y. Tian, D. Wang, J. Li, C. Shi, H. Zhao, X. Niu and Z. Li, Chem. Commun., 2016, 52, 9275 DOI: 10.1039/C6CC04672J
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