Issue 68, 2016
From the journal:

Chemical Communications

Mitochondria-targeting ratiometric fluorescent probe for γ-glutamyltranspeptidase and its application to colon cancer†

Seokan Park,a   Dong Jun Bae,b   Yeon-Mi Ryu,b   Sang-Yeob Kim,bc   Seung-Jae Myung*bd  and  Hae-Jo Kim*a  

* Corresponding authors

a Department of Chemistry, Hankuk University of Foreign Studies, Yongin 449-791, Korea
E-mail: haejkim@hufs.ac.kr
Fax: +82-31-3304566
Tel: +82-31-3304703

b ASAN Institute for Life Sciences, ASAN Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea

c Department of Convergence Medicine, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea

d Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea
E-mail: sjmyung@amc.seoul.kr
Fax: +82 2 476 0824
Tel: +82 2 3010 3917

Abstract

A mitochondria-targeting ratiometric probe was designed for γ-glutamyltranspeptidase (γGT). Mechanistic study by HPLC and an inhibitor assay showed that the probe underwent γGT-mediated amide-to-amine transformation and induced a ratiometric fluorescence response in cellular mitochondria. Further application was successful for the detection of cancerous colons in mice.

Graphical abstract: Mitochondria-targeting ratiometric fluorescent probe for γ-glutamyltranspeptidase and its application to colon cancer

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Article information

DOI
https://doi.org/10.1039/C6CC05573G
Article type
Communication
Submitted
05 Jul 2016
Accepted
19 Jul 2016
First published
19 Jul 2016

Chem. Commun., 2016,52, 10400-10402

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Mitochondria-targeting ratiometric fluorescent probe for γ-glutamyltranspeptidase and its application to colon cancer

S. Park, D. J. Bae, Y. Ryu, S. Kim, S. Myung and H. Kim, Chem. Commun., 2016, 52, 10400 DOI: 10.1039/C6CC05573G

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