Issue 75, 2016
From the journal:

Chemical Communications

A biotin-guided formaldehyde sensor selectively detecting endogenous concentrations in cancerous cells and tissues†

Yun Hak Lee,‡a   Yonghe Tang,‡b   Peter Verwilst, ORCID logo ‡a   Weiying Lin*b  and  Jong Seung Kim*a  

* Corresponding authors

a Department of Chemistry, Korea University, Seoul 136-701, Korea
E-mail: jongskim@korea.ac.kr

b Institute of Fluorescent Probes for Biological Imaging, School of Chemistry and Chemical Engineering, School of Biological Science and Technology, University of Jinan, Shandong 250022, P. R. China
E-mail: weiyinglin2013@163.com

Abstract

A biotin appended formaldehyde sensor was found to specifically visualise both exogenous and endogenous levels of formaldehyde in biotin receptor positive cells over biotin negative cells by means of one- and two-photon excitation. The probe furthermore visualised endogenous levels of formaldehyde in tumour tissue slices up to 70 μm depth.

Graphical abstract: A biotin-guided formaldehyde sensor selectively detecting endogenous concentrations in cancerous cells and tissues

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Article information

DOI
https://doi.org/10.1039/C6CC06158C
Article type
Communication
Submitted
26 Jul 2016
Accepted
17 Aug 2016
First published
17 Aug 2016

Chem. Commun., 2016,52, 11247-11250

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A biotin-guided formaldehyde sensor selectively detecting endogenous concentrations in cancerous cells and tissues

Y. H. Lee, Y. Tang, P. Verwilst, W. Lin and J. S. Kim, Chem. Commun., 2016, 52, 11247 DOI: 10.1039/C6CC06158C

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