A CoII complex for 19F MRI-based detection of reactive oxygen species

Meng Yu; Da Xie; Khanh P. Phan; José S. Enriquez; Jeffrey J. Luci; Emily L. Que

doi:10.1039/C6CC08207F

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A Co^II complex for ¹⁹F MRI-based detection of reactive oxygen species†

Meng Yu,^a Da Xie,^a Khanh P. Phan,^a José S. Enriquez,^a Jeffrey J. Luci^bc and Emily L. Que*^a

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* Corresponding authors

^a Department of Chemistry, The University of Texas at Austin, 105 E. 24th St. Stop A5300, Austin, TX 78712, USA
E-mail: emilyque@cm.utexas.edu

^b Department of Neuroscience, The University of Texas at Austin, Austin, TX 78712, USA

^c Imaging Research Center, The University of Texas at Austin, Austin, TX 78712, USA

Abstract

A fluorinated, air-stable cobalt(II) complex serves as a turn-on ¹⁹F magnetic resonance imaging (MRI) tracer for reactive oxygen species including H₂O₂. Upon oxidation with H₂O₂, the complex converts from paramagnetic high spin Co^II to diamagnetic low spin Co^III resulting in a chemical shift change and enhancement in ¹⁹F NMR signal. Further, the oxidation can be reversed in the presence of reductant Na₂S₂O₄. The turn-on response is demonstrated by ¹⁹F MRI, characterized by a ∼2–3 fold enhancement in signal.

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Article information

DOI: https://doi.org/10.1039/C6CC08207F
Article type: Communication
Submitted: 11 Oct 2016
Accepted: 08 Nov 2016
First published: 08 Nov 2016

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Chem. Commun., 2016,52, 13885-13888

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A Co^II complex for ¹⁹F MRI-based detection of reactive oxygen species

M. Yu, D. Xie, K. P. Phan, J. S. Enriquez, J. J. Luci and E. L. Que, Chem. Commun., 2016, 52, 13885 DOI: 10.1039/C6CC08207F

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