Issue 9, 2016

Crystal engineered albendazole with improved dissolution and material attributes

Abstract

Albendazole (ABZ) is a broad spectrum anthelminthic drug and is in the WHO list of essential medicines. It is a “brick dust” drug with very poor water solubility (0.2 pg ml−1 at 25 °C). In the present study, crystal engineering of ABZ was carried out using two different techniques: solvent recrystallization and spherical agglomeration. All the modified habits have shown improved dissolution and flow properties. Spherical agglomerates with HPC as a binder have shown a 5.60 fold enhancement in dissolution efficiency at the end of 6 h when compared to ABZ. The agglomerates with binder showed good compressibility and can be successfully used for direct tabletting.

Graphical abstract: Crystal engineered albendazole with improved dissolution and material attributes

Supplementary files

Article information

Article type
Communication
Submitted
26 Nov 2015
Accepted
15 Jan 2016
First published
21 Jan 2016

CrystEngComm, 2016,18, 1489-1494

Crystal engineered albendazole with improved dissolution and material attributes

A. Thakur, R. Thipparaboina, D. Kumar, K. Sai Gouthami and N. R. Shastri, CrystEngComm, 2016, 18, 1489 DOI: 10.1039/C5CE02306H

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