Issue 15, 2016
From the journal:

Physical Chemistry Chemical Physics

Kinetic isotope effects for fast deuterium and proton exchange rates

Estel Canet,*abcd   Daniele Mammoli,a   Pavel Kadeřávek,abcd   Philippe Pelupessybcd  and  Geoffrey Bodenhausenabcd  

* Corresponding authors

a Ecole Polytechinque Fédérale de Lausanne, Laboratoire de Résonance Magnétique Biomoléculaire, Batochime, CH-1015 Lausanne, Switzerland
E-mail: estel.canet@epfl.ch

b Ecole Normale Supérieure – PSL Research University, Département de Chimie, 24 rue Lhomond, 75231 Paris Cedex 05, France

c Sorbonne Universités, UPMC Univ Paris 06, LBM, 4 place Jussieu, 75005 Paris, France

d CNRS, UMR 7203 LBM, 75005 Paris, France

Abstract

By monitoring the effect of deuterium decoupling on the decay of transverse 15N magnetization in D–15N spin pairs during multiple-refocusing echo sequences, we have determined fast D–D exchange rates kD and compared them with fast H–H exchange rates kH in tryptophan to determine the kinetic isotope effect as a function of pH and temperature.

Graphical abstract: Kinetic isotope effects for fast deuterium and proton exchange rates

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Article information

DOI
https://doi.org/10.1039/C5CP07459B
Article type
Paper
Submitted
03 Dec 2015
Accepted
08 Mar 2016
First published
09 Mar 2016
This article is Open Access
Creative Commons BY license

Phys. Chem. Chem. Phys., 2016,18, 10144-10151

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Kinetic isotope effects for fast deuterium and proton exchange rates

E. Canet, D. Mammoli, P. Kadeřávek, P. Pelupessy and G. Bodenhausen, Phys. Chem. Chem. Phys., 2016, 18, 10144 DOI: 10.1039/C5CP07459B

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