Issue 2, 2016

The effects of polysaccharides from the root of Angelica sinensis on tumor growth and iron metabolism in H22-bearing mice

Abstract

The crude polysaccharide was obtained from the root of Angelica sinensis (AS) to investigate its effect on tumor growth and iron metabolism in H22-bearing mice. In our study, we showed that Angelica sinensis polysaccharide (ASP) was mainly composed of arabinose, glucose and galactose in a molar ratio of 1 : 1 : 1.75, with a molecular weight of 80 900 Da and a sugar content of 88.0%. Animal experimental results revealed that three doses of ASP all had anti-tumor effects with inhibition ratios of 27.11%, 31.65% and 37.05%. With respect to iron metabolism, the mean levels of serum hepcidin, interleukin-6 (IL-6), ferritin, transferrin (Tf), transferrin receptor 1 (TfR1) and transferrin receptor 2 (TfR2) in H22-bearing mice were promoted, and serum iron concentration decreased significantly. After treatment with ASP, these iron-related indicators recovered in different degrees. The findings suggested that the anti-tumor activity of ASP may be affected by its regulation on iron metabolism in H22-bearing mice.

Graphical abstract: The effects of polysaccharides from the root of Angelica sinensis on tumor growth and iron metabolism in H22-bearing mice

Article information

Article type
Paper
Submitted
14 Jul 2015
Accepted
24 Dec 2015
First published
04 Jan 2016

Food Funct., 2016,7, 1033-1039

The effects of polysaccharides from the root of Angelica sinensis on tumor growth and iron metabolism in H22-bearing mice

Y. Cheng, J. Zhou, Q. Li, Y. Liu, K. Wang and Y. Zhang, Food Funct., 2016, 7, 1033 DOI: 10.1039/C5FO00855G

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