Issue 7, 2016
From the journal:

Green Chemistry

Methyl NFSI: atom-economical alternative to NFSI shows higher fluorination reactivity under Lewis acid-catalysis and non-catalysis†

Kazunobu Fukushi,a   Satoru Suzuki,a   Tomohiro Kamo,a   Etsuko Tokunaga,b   Yuji Sumii,a   Takumi Kagawa,c   Kosuke Kawadac  and  Norio Shibata*ab  

* Corresponding authors

a Department of Nanopharmaceutical Sciences, Nagoya Institute of Technology (NIT), Gokiso, Showa-ku, Nagoya 466-8555, Japan
E-mail: nozshiba@nitech.ac.jp
Fax: +81-52-735-7543

b Department of Frontier Materials, Nagoya Institute of Technology (NIT), Gokiso, Showa-ku, Nagoya 466-8555, Japan

c TOSOH F-TECH, Inc., 4988, Kaisei-cho, Shunan, Yamaguchi 746-0006, Japan
Fax: +81-834-62-1303
Tel: +81-834-62-1300

Abstract

Me-NFSI was first reported in 1994. Despite its atom-economical structure and similarity to a well-explored fluorinating reagent, NFSI, Me-NFSI has not appeared in the literature in over 20 years. We disclose that Me-NFSI is more effective for the fluorination of active methines under Lewis acid-catalysis and non-catalysis than NFSI.

Graphical abstract: Methyl NFSI: atom-economical alternative to NFSI shows higher fluorination reactivity under Lewis acid-catalysis and non-catalysis

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Article information

DOI
https://doi.org/10.1039/C5GC02612A
Article type
Communication
Submitted
30 Oct 2015
Accepted
18 Nov 2015
First published
19 Nov 2015

Green Chem., 2016,18, 1864-1868

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Methyl NFSI: atom-economical alternative to NFSI shows higher fluorination reactivity under Lewis acid-catalysis and non-catalysis

K. Fukushi, S. Suzuki, T. Kamo, E. Tokunaga, Y. Sumii, T. Kagawa, K. Kawada and N. Shibata, Green Chem., 2016, 18, 1864 DOI: 10.1039/C5GC02612A

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