Iron-catalyzed carbonylation of aryl halides with arylborons using stoichiometric chloroform as the carbon monoxide source

Abstract

A general iron-catalyzed carbonylative Suzuki–Miyaura coupling of aryl halides with arylborons is reported, using stoichiometric CHCl₃ as the CO source. The high efficiency, economy, selectivity, and operational simplicity of this transformation make this method a valuable tool in organic synthesis. Importantly, the presented strategy allows effective ¹³C labeling simply by using the commercially available ¹³C-labeled CHCl₃. On the basis of the initial mechanistic exploration, an aryl radical intermediate is proposed in the present carbonylation process.