Electrocatalytic redox behavior of graphene films towards acebutolol hydrochloride determination in real samples

Abstract

The electrochemical behavior of acebutolol (ACBT) at a thin graphene film modified glassy carbon electrode (GF-GCE) has been investigated using cyclic and differential pulse voltammetric techniques. An excellent electrocatalytic activity of the GF-GCE towards the determination of lower concentrations of acebutolol in the physiological solution medium was investigated. Factors such as pH, scan rate and concentration, which influence the detection of ACBT, were studied. Variation of scan rate revealed that the oxidation reaction involving two electrons – four protons transfer was adsorption controlled. Under optimal conditions, GF-GCE exhibited a longer linearity range from 3.36 to 57.12 ng mL⁻¹ of ACBT with a limit of detection of 0.131 ng mL⁻¹. The present method was successfully applied for acebutolol determination in pharmaceuticals and real samples.