Issue 25, 2016
From the journal:

Nanoscale

A highly fluorescent AIE-active theranostic agent with anti-tumor activity to specific cancer cells†

Yueyue Zhao,‡ab   Ryan T. K. Kwok,‡ab   Jacky W. Y. Lamab  and  Ben Zhong Tang*abc  

* Corresponding authors

a HKUST Shenzhen Research Institute, No. 9 Yuexing 1st Road, South Area, Hi-tech Park, Nanshan, Shenzhen 518057, China
E-mail: tangbenz@ust.hk

b Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Institute for Advanced Study, Division of Biomedical Engineering, Division of Life Science, State Key Laboratory of Molecular Neuroscience, Institute of Molecular Functional Materials, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China

c Guangdong Innovative Research Team, SCUT-HKUST Joint Research Laboratory, State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou 510640, China

Abstract

A tetraphenylethene derivative with a structure resembling Tamoxifen is designed and synthesized as a theranostic agent for cell imaging and anti-breast cancer therapy. Its high brightness, excellent photostability and long-term cell tracing properties enable elucidation of its working mechanism and hence provide new insights into drug development.

Graphical abstract: A highly fluorescent AIE-active theranostic agent with anti-tumor activity to specific cancer cells

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Article information

DOI
https://doi.org/10.1039/C5NR08782A
Article type
Communication
Submitted
10 Dec 2015
Accepted
07 Jan 2016
First published
08 Jan 2016

Nanoscale, 2016,8, 12520-12523

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A highly fluorescent AIE-active theranostic agent with anti-tumor activity to specific cancer cells

Y. Zhao, R. T. K. Kwok, J. W. Y. Lam and B. Z. Tang, Nanoscale, 2016, 8, 12520 DOI: 10.1039/C5NR08782A

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