A novel DBU-mediated oxidative cyanation of α-amino carbonyl compounds by using air as the sole oxidant was developed under mild metal-free conditions for the first time. The reaction involves a tandem oxidation/Strecker reaction/oxidation process and provides a new and efficient method for the construction of α-iminonitriles in good to high yields in a single step.
L. Li, Q. Wang, P. Liu, H. Meng, X. Kan, Q. Liu and Y. Zhao, Org. Biomol. Chem., 2016, 14, 165 DOI: 10.1039/C5OB01690H
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