In contrast to a biomimetic electrophilic cyclisation cascade, we employ a contra-biomimetic nucleophilic cyclisation cascade to give the tricyclic core of 4-hydroxy-GR24 in a single step. Kinetic resolution using a stereoselective Noyori transfer hydrogenation enables the concise synthesis of any enantiomerically enriched 4-hydroxy-GR24 stereoisomer.
J. C. Morris and C. S. P. McErlean, Org. Biomol. Chem., 2016, 14, 1236 DOI: 10.1039/C5OB02349A
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