A practical and convergent asymmetric route to calcium atorvastatin (1) is reported. The synthesis of calcium atorvastatin (1) was performed using the remote 1,5-anti asymmetric induction in the boron-mediated aldol reaction of β-alkoxy methylketone (4) with pyrrolic aldehyde (3) as a key step. Calcium atorvastatin was obtained from aldehyde (3) after 6 steps, with a 41% overall yield.
L. C. Dias, A. S. Vieira and E. J. Barreiro, Org. Biomol. Chem., 2016, 14, 2291 DOI: 10.1039/C5OB02546J
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