Issue 29, 2016

Synthesis and self-assembly of DNA–chromophore hybrid amphiphiles

Abstract

DNA based spherical nanostructures are one of the promising nanostructures for several biomedical and biotechnological applications due to their excellent biocompatibility and DNA-directed surface addressability. Herein, we report the synthesis and amphiphilicity-driven self-assembly of two classes of DNA (hydrophilic)–chromophore (hydrophobic) hybrid amphiphiles into spherical nanostructures. A solid-phase “click” chemistry based modular approach is demonstrated for the synthesis of DNA–chromophore amphiphiles. Various spectroscopic and microscopic analyses reveal the self-assembly of the amphiphiles into vesicular and micellar assemblies with the corona made of hydrophilic DNA and the hydrophobic chromophoric unit as the core of the spherical nanostructures.

Graphical abstract: Synthesis and self-assembly of DNA–chromophore hybrid amphiphiles

Supplementary files

Article information

Article type
Paper
Submitted
31 Mar 2016
Accepted
23 May 2016
First published
23 May 2016

Org. Biomol. Chem., 2016,14, 6960-6969

Synthesis and self-assembly of DNA–chromophore hybrid amphiphiles

S. K. Albert, M. Golla, H. V. P. Thelu, N. Krishnan, P. Deepak and R. Varghese, Org. Biomol. Chem., 2016, 14, 6960 DOI: 10.1039/C6OB00681G

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