TMG-catalyzed [3 + 2] organocatalytic 1,3-dipolar cycloaddition reactions of β-functionalized ketones with nitrile oxides have been developed. This strategy could generate 3,4,5-trisubstituted isoxazoles in high yields and regioselectivities.
X. Zhou, X. Xu, Z. Shi, K. Liu, H. Gao and W. Li, Org. Biomol. Chem., 2016, 14, 5246 DOI: 10.1039/C6OB00717A
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