An efficient method for removal of the hydrazine group from (hetero)aromatic substrates has been developed. It can be realized both on a solid support and in solution by synthesis employing a low concentration solution of trimethylsilanolate in tetrahydrofuran or N,N-dimethylformamide. For water-soluble substrates, the reaction can be performed in water, highlighting the eco-friendly attributes of this methodology.
L. Kubovičová, K. Bürglová and J. Hlaváč, Org. Biomol. Chem., 2016, 14, 4824 DOI: 10.1039/C6OB00737F
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