Azogabazine; a photochromic antagonist of the GABAA receptor

Abstract

The design and synthesis of azogabazine is described, which represents a highly potent (IC₅₀ = 23 nM) photoswitchable antagonist of the GABA_A receptor. An azologization strategy is adopted, in which a benzyl phenyl ether in a high affinity gabazine analogue is replaced by an azobenzene, with resultant retention of antagonist potency. We show that cycling from blue to UV light, switching between trans and cis isomeric forms, leads to photochemically controlled antagonism of the GABA ion channel.