Issue 38, 2016
From the journal:

Organic & Biomolecular Chemistry

Stabilized pyrrolyl iodonium salts and metal-free oxidative cross-coupling†

Koji Morimoto,a   Yusuke Ohnishi,a   Daichi Koseki,a   Akira Nakamura,b   Toshifumi Dohia  and  Yasuyuki Kita ORCID logo *b  

* Corresponding authors

a Ritsumeikan University, College of Pharmaceutical Sciences, 1-1-1 Nojihigashi, Kusatsu, Shiga 525-8577, Japan

b Ritsumeikan University, Research Organization of Science and Technology, 1-1-1 Nojihigashi, Kusatsu, Shiga, Japan
E-mail: kita@ph.ritsumei.ac.jp
Fax: +81-77-561-5829
Tel: +81-77-561-5829

Abstract

Pyrrole–aryl derivatives are important due to their unique biological activities in medicinal chemistry. We now report a new oxidative biaryl coupling for pyrroles and indoles toward various arenes using a hypervalent iodine reagent and an appropriate stabilizer for pyrrolyl iodonium intermediates. The reactions readily provide a variety of desired coupling products in good yields.

Graphical abstract: Stabilized pyrrolyl iodonium salts and metal-free oxidative cross-coupling

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C6OB01764A
Article type
Communication
Submitted
13 Aug 2016
Accepted
06 Sep 2016
First published
12 Sep 2016

Org. Biomol. Chem., 2016,14, 8947-8951

Permissions

Request permissions

Stabilized pyrrolyl iodonium salts and metal-free oxidative cross-coupling

K. Morimoto, Y. Ohnishi, D. Koseki, A. Nakamura, T. Dohi and Y. Kita, Org. Biomol. Chem., 2016, 14, 8947 DOI: 10.1039/C6OB01764A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements