Issue 1, 2016

Copper-mediated C(sp3)–H amination in a multiple C–N bond-forming strategy for the synthesis of N-heterocycles

Abstract

An efficient construction of imidazo[1,5-a]pyridines, through a three-component reaction involving benzyl substituted pyridines, aldehydes, and TMSN3, has been developed. Three C–N bonds were formed in one pot. Copper-promoted amination of the benzylic C(sp3)–H bond is a key step of this multiple C–N bond-forming sequence.

Graphical abstract: Copper-mediated C(sp3)–H amination in a multiple C–N bond-forming strategy for the synthesis of N-heterocycles

Supplementary files

Article information

Article type
Research Article
Submitted
13 Oct 2015
Accepted
18 Nov 2015
First published
20 Nov 2015

Org. Chem. Front., 2016,3, 82-86

Author version available

Copper-mediated C(sp3)–H amination in a multiple C–N bond-forming strategy for the synthesis of N-heterocycles

Z. Xie, J. Peng and Q. Zhu, Org. Chem. Front., 2016, 3, 82 DOI: 10.1039/C5QO00313J

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