An organocatalytic enantioselective vinylogous Mannich reaction of α,α-dicyanoolefins with isatin N-Boc ketimines

Abstract

The first catalytic enantioselective vinylogous Mannich reaction of α,α-dicyanoolefins with ketimines derived from isatins has been developed. High yields and enantioselectivities were observed for the reaction of various ketimines and α,α-dicyanoolefins using a tertiary butyl substituted cinchona alkaloid type squaramide catalyst.