Issue 8, 2016
From the journal:

Organic Chemistry Frontiers

Iron-catalyzed trifluoromethylation of vinylcyclopropanes: facile synthesis of CF3–containing dihydronaphthalene derivatives†

Zong-Rui Li,a   Xing-Xing Bao,b   Jian Sun,a   Jing Shen,a   Dun-Qi Wu,a   Yan-Kai Liu,a   Qing-Hai Deng*a  and  Feng Liu*b  

* Corresponding authors

a The Education Ministry Key Lab of Resource Chemistry and Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University, Shanghai 200234, P. R. China
E-mail: qinghaideng@hotmail.com

b Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases and Department of Medicinal Chemistry, College of Pharmaceutical Sciences, Soochow University, 199 Ren-Ai Road, Suzhou, Jiangsu 215123, People's Republic of China
E-mail: fliu2@suda.edu.cn

Abstract

An efficient Fe(II)-catalyzed trifluoromethylation of vinylcyclopropanes was successfully developed. A series of CF3-containing dihydronaphthalene derivatives were prepared in moderate to high yields (up to 96%) under mild reaction conditions using the Togni reagent as the CF3 source.

Graphical abstract: Iron-catalyzed trifluoromethylation of vinylcyclopropanes: facile synthesis of CF3–containing dihydronaphthalene derivatives

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Article information

DOI
https://doi.org/10.1039/C6QO00166A
Article type
Research Article
Submitted
19 Apr 2016
Accepted
20 May 2016
First published
23 May 2016

Org. Chem. Front., 2016,3, 934-938

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Iron-catalyzed trifluoromethylation of vinylcyclopropanes: facile synthesis of CF3–containing dihydronaphthalene derivatives

Z. Li, X. Bao, J. Sun, J. Shen, D. Wu, Y. Liu, Q. Deng and F. Liu, Org. Chem. Front., 2016, 3, 934 DOI: 10.1039/C6QO00166A

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