Issue 12, 2016
From the journal:

Organic Chemistry Frontiers

Silver(i)-promoted C5–H phosphonation of 8-aminoquinoline amides with H-phosphonates†

Mengmeng Sun,a   Suyan Sun,a   Huijie Qiao,a   Fan Yang,*a   Yu Zhu,a   Jianxun Kang,a   Yusheng Wu*bc  and  Yangjie Wu*a  

* Corresponding authors

a The College of Chemistry and Molecular Engineering, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Zhengzhou University, Zhengzhou 450052, China
E-mail: yangf@zzu.edu.cn, wyj@zzu.edu.cn

b Tetranov Biopharm, LLC., 75 Daxue Road, Zhengzhou, China
E-mail: yusheng.wu@tetranovglobal.com

c Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, China
E-mail: yusheng.wu@tetranovglobal.com

Abstract

A simple and efficient protocol for silver(I)-promoted phosphonation of 8-aminoquinoline amides with dialkyl H-phosphonates has been developed, affording the desired products in moderate yields. This method features C5–H regioselectivity of 8-aminoquinoline amides, a broad substrate scope and general functional group compatibility.

Graphical abstract: Silver(i)-promoted C5–H phosphonation of 8-aminoquinoline amides with H-phosphonates

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Article information

DOI
https://doi.org/10.1039/C6QO00379F
Article type
Research Article
Submitted
21 Jul 2016
Accepted
15 Sep 2016
First published
19 Sep 2016

Org. Chem. Front., 2016,3, 1646-1650

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Silver(I)-promoted C5–H phosphonation of 8-aminoquinoline amides with H-phosphonates

M. Sun, S. Sun, H. Qiao, F. Yang, Y. Zhu, J. Kang, Y. Wu and Y. Wu, Org. Chem. Front., 2016, 3, 1646 DOI: 10.1039/C6QO00379F

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