A sensitive electrochemical sensor for the determination of carvedilol based on a modified glassy carbon electrode with ordered mesoporous carbon

Abstract

This work describes the incorporation of ordered mesoporous carbon (OMC) as a sensing material for carvedilol (CAR) detection on a glassy carbon electrode (GCE). The physicochemical properties of the prepared OMC as the modifier layer on GCE was studied by X-ray diffraction spectroscopy (XRD), N₂ adsorption–desorption and scanning electron microscopy (SEM) techniques. The effective surface area for OMC/GCE was enhanced compared with bare GCE. The electrochemical sensor was sensitive to CAR in the range of 0.1–23.0 μmol L⁻¹ with a detection limit of 0.034 μmol L⁻¹. Also the effect of some interfering compounds such as glucose, lactose, glycine, valine and others, on the determination of CAR was studied, and none of them had a significant effect on the assay recovery. Moreover, its practical applicability was reliable, which is desirable for analysis of biological fluids and pharmaceutical samples.