Issue 23, 2016

Cyclopentadienyl iron dicarbonyl (CpFe(CO)2) derivatives as apoptosis-inducing agents

Abstract

Iron has been found to serve multiple purposes besides being an oxygen carrier. Of particular note is the generation of deleterious free radicals which can lead to the formation of tumours. However, in this work, we have found that cyclopentadienyl iron carbonyl complexes CpFe(CO)2X (X = halide, NCS, BF4 and CpFe(CO)2) can induce apoptosis in breast cancer and HeLa cell lines. Normal cells are however unaffected. A detailed study on CpFe(CO)2I shows that the complex is metabolic-stable and easily permeable across a lipid barrier. Preliminary investigations into the mode of action suggest that a Fenton-type reaction caused by CpFe(CO)2 complexes may be related to cell death.

Graphical abstract: Cyclopentadienyl iron dicarbonyl (CpFe(CO)2) derivatives as apoptosis-inducing agents

Supplementary files

Article information

Article type
Paper
Submitted
12 Nov 2015
Accepted
05 Feb 2016
First published
09 Feb 2016

RSC Adv., 2016,6, 18814-18823

Author version available

Cyclopentadienyl iron dicarbonyl (CpFe(CO)2) derivatives as apoptosis-inducing agents

H. T. Poh, P. C. Ho and W. Y. Fan, RSC Adv., 2016, 6, 18814 DOI: 10.1039/C5RA23891A

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