Issue 3, 2016

Fluorescence dye loaded nano-graphene for multimodal imaging guided photothermal therapy

Abstract

Photoacoustic imaging (PA) has emerged as a novel and noninvasive imaging modality owing to its high spatial resolution and high soft tissue contrast. Herein, we loaded a near-infrared (NIR) fluorescence dye (CySCOOH) onto the surface of PEGylated graphene oxide (GO) via π–π stacking to increase the NIR absorbance of GO. The PA imaging proved that PEGylated GO-CysCOOH (GO-PEG-CysCOOH) significantly enhances the PA signal in the tumor site compared with free GO-PEG. We then utilized the strong optical absorbance of GO-PEG-CySCOOH in the NIR region for in vivo photothermal therapy, achieving efficient tumor ablation after intravenous injection of GO-PEG-CySCOOH and low-power laser irradiation on the tumor. Our results indicate that this graphene-based nanocomposite can be developed as a promising contrast agent for PA imaging and a thermal agent for imaging guided photothermal therapy.

Graphical abstract: Fluorescence dye loaded nano-graphene for multimodal imaging guided photothermal therapy

Supplementary files

Article information

Article type
Paper
Submitted
22 Nov 2015
Accepted
16 Dec 2015
First published
21 Dec 2015

RSC Adv., 2016,6, 1894-1901

Fluorescence dye loaded nano-graphene for multimodal imaging guided photothermal therapy

P. Rong, J. Wu, Z. Liu, X. Ma, L. Yu, K. Zhou, W. Zeng and W. Wang, RSC Adv., 2016, 6, 1894 DOI: 10.1039/C5RA24752G

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