Issue 16, 2016
From the journal:

RSC Advances

Self-assembled nanospheres for encapsulation and aerosolization of rifampicin†

Aline A. Ishikawa,ae   J. Jesus Velazquez Salazar,b   Magaly Salinas,c   Cristiane M. Gaitani,a   Timothy R. Nurkiewicz,d   George R. Negrete*c  and  Carlos D. Garcia*e  

* Corresponding authors

a School of Pharmaceutical Sciences of Ribeirão Preto, Ribeirao Preto, SP, Brazil

b Department of Physics and Astronomy, UT San Antonio, San Antonio, TX, USA

c Department of Chemistry, UT San Antonio, San Antonio, TX, USA
E-mail: george.negrete@utsa.edu

d Department of Physiology & Pharmacology, Center for Cardiovascular & Respiratory Sciences, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV, USA

e Department of Chemistry, Clemson University, Clemson, SC 29634, USA
E-mail: cdgarci@clemson.edu

Abstract

Rifampicin (RIF) is a benchmark drug for treatment of tuberculosis, but poor bioavailability, prolonged treatment, and pill burden have been linked to therapeutic failure and the development of multidrug resistant strains. To overcome these limitations, this study investigated a method of rifampicin nanoencapsulation and aerosol delivery using a commercial, hand-held nebulizer modified with a nitrogen stream.

Graphical abstract: Self-assembled nanospheres for encapsulation and aerosolization of rifampicin

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Article information

DOI
https://doi.org/10.1039/C5RA25044G
Article type
Communication
Submitted
25 Nov 2015
Accepted
21 Jan 2016
First published
26 Jan 2016

RSC Adv., 2016,6, 12959-12963

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Self-assembled nanospheres for encapsulation and aerosolization of rifampicin

A. A. Ishikawa, J. J. Velazquez Salazar, M. Salinas, C. M. Gaitani, T. R. Nurkiewicz, G. R. Negrete and C. D. Garcia, RSC Adv., 2016, 6, 12959 DOI: 10.1039/C5RA25044G

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