Schoberine B, an alkaloid with an unprecedented straight C5 side chain, and myriberine B from Myrioneuron faberi

Abstract

Two novel Myrioneuron alkaloids, schoberine B (1) and myriberine B (2), were isolated from the aerial part of Myrioneuron faberi. Schoberine B is the first example among lysine-originating alkaloids to possess a ring-free C₅ fragment as a side chain. The structures of 1 and 2 were elucidated using analyses of extensive NMR and MS spectra. 1 and 2 were evaluated in vitro against hepatitis C virus (HCV), showing a therapeutic index (CC₅₀/EC₅₀) of higher than 36.2 and 15.2, respectively.