Hypersampsones S–W, new polycyclic polyprenylated acylphloroglucinols from Hypericum sampsonii

Abstract

Five new polycyclic polyprenylated acylphloroglucinols (1–5) with a bicyclo[3.3.1]nonane skeleton, along with five known analogues (6–10), were isolated from the aerial parts of Hypericum sampsonii. Their structures, including the absolute configurations of 1–5, were elucidated by spectroscopic analysis, modified Mosher's method, ECD calculations and in situ dimolybdenum CD method. Besides, all the compounds were evaluated for RXRα transcriptional-inhibitory activities and cytotoxicity against HeLa cells.