Phosphine-catalyzed domino reactions of alkynyl ketones with sulfonylhydrazones: construction of diverse pyrazoloquinazoline derivatives†
Abstract
An efficient method for the synthesis of C-1 position acyl substituted pyrazoloquinazoline derivatives via a PBu3-promoted regioselective domino process of sulfonylhydrazones and alkynyl ketones was developed, which may be potentially useful for drug discovery.