One-pot synthesis and loading of mesoporous SiO2 nanocontainers using micellar drugs as a template

Abstract

A new approach is proposed for creating of pH-sensitive mesoporous silica nanocontainers with ultrahigh capacity for amphiphilic functional compounds. It relies on the use of micelles of such compounds as templates for the sol–gel synthesis of SiO₂ nanoparticles. The possibility of such one-stage synthesis and loading of SiO₂ nanocontainers has been demonstrated using the micelles of the bactericidal drug Myramistin as a template.