Fe3O4@nanogel via UOx/HRP initiated surface polymerization for pH sensitive drug delivery

Qing Wu; Zhaoqi Wang; Haixia Zhang; Rongrong Zhu; Shilong Wang; Qigang Wang

doi:10.1039/C6RA06331D

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Fe₃O₄@nanogel via UOx/HRP initiated surface polymerization for pH sensitive drug delivery†

Qing Wu,^a Zhaoqi Wang,^a Haixia Zhang,^a Rongrong Zhu,^a Shilong Wang*^a and Qigang Wang*^a

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* Corresponding authors

^a Department of Chemistry, School of Life Science and Technology, Tongji University, Shanghai 200092, China
E-mail: wsl@tongji.edu.cn, wangqg66@tongji.edu.cn

Abstract

This communication describes a new strategy to fabricate a nanogel layer around magnetic nanoparticles by surface free-radical polymerization triggered by the cascade reaction of urate oxidase and horseradish peroxidase, which showed high loading capacity, pH-responsive drug release and low cytotoxicity.

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Article information

DOI: https://doi.org/10.1039/C6RA06331D
Article type: Communication
Submitted: 09 Mar 2016
Accepted: 23 May 2016
First published: 25 May 2016

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RSC Adv., 2016,6, 53170-53174

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Fe₃O₄@nanogel via UOx/HRP initiated surface polymerization for pH sensitive drug delivery

Q. Wu, Z. Wang, H. Zhang, R. Zhu, S. Wang and Q. Wang, RSC Adv., 2016, 6, 53170 DOI: 10.1039/C6RA06331D

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