Total synthesis of (−)-(6R,11R,14S)-colletallol via proline catalyzed α-aminoxylation and Yamaguchi macrolactonization†
Abstract
A simple and efficient synthesis of the 14-membered macrolide (−)-(6R,11R,14S)-colletallol was achieved in a highly diastereoselective manner with high overall yield. The stereogenic centre was generated using a proline catalyzed α-aminoxylation reaction and the ring was constructed using Yamaguchi protocol.