Role of surfactant and micelle promoted mild, green, highly efficient and sustainable approach for construction of novel fused pyrimidines at room temperature in water

Abstract

A facile, efficient and green protocol for surfactant catalyzed synthesis of fused pyrimidines in water at room temperature was developed for the first time. The influence of the sodium lauryl sulphate (SLS) micelles and their different concentrations on reactivity was studied. It was found that best yield was obtained with 10 mol% catalyst loading with minimum time as compare to other surfactants and catalysts were used. This procedure resulted in a general and environmentally benign protocol has advantage of better efficiency of catalyst, excellent yield, short reaction time and easy to work up.