Issue 66, 2016, Issue in Progress
From the journal:

RSC Advances

Identification of new p300 histone acetyltransferase inhibitors from natural products by a customized virtual screening method†

Guo-Bo Li,a   Lu-Yi Huang,a   Hui Li,a   Sen Ji,a   Lin-Li Lib  and  Sheng-Yong Yang*a  

* Corresponding authors

a State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, West China Medical School, Sichuan University, Sichuan 610041, China
E-mail: yangsy@scu.edu.cn
Fax: +86-28-85164060
Tel: +86-28-85164063

b Key Laboratory of Drug Targeting and Drug Delivery System of Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan, China

Abstract

Herein, we sought to discover new p300 HAT inhibitors from natural products by a customized structure-based virtual screening method. The natural compounds NP-2 (spinosine), NP-3 (palmatine), NP-9 (venenatine), and NP-15 (taxodione) were found to be potent p300 HAT inhibitors, of which IC50 values are 0.69 μM, 1.05 μM, 0.58 μM, 4.85 μM, respectively.

Graphical abstract: Identification of new p300 histone acetyltransferase inhibitors from natural products by a customized virtual screening method

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Article information

DOI
https://doi.org/10.1039/C6RA11240D
Article type
Communication
Submitted
30 Apr 2016
Accepted
17 Jun 2016
First published
20 Jun 2016

RSC Adv., 2016,6, 61137-61140

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Identification of new p300 histone acetyltransferase inhibitors from natural products by a customized virtual screening method

G. Li, L. Huang, H. Li, S. Ji, L. Li and S. Yang, RSC Adv., 2016, 6, 61137 DOI: 10.1039/C6RA11240D

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