Issue 68, 2016, Issue in Progress
From the journal:

RSC Advances

Functionalization of pyridyl ketones using deprotolithiation-in situ zincation†

Madani Hedidi,‡ab   William Erb,*a   Frédéric Lassagne,a   Yury S. Halauko,*c   Oleg A. Ivashkevich,c   Vadim E. Matulis,d   Thierry Roisnel,e   Ghenia Bentabed-Ababsa*b  and  Florence Mongina  

* Corresponding authors

a Chimie et Photonique Moléculaires, Institut des Sciences Chimiques de Rennes, UMR 6226, Université de Rennes 1-CNRS, Bâtiment 10A, Case 1003, Campus de Beaulieu, 35042 Rennes, France
E-mail: william.erb@univ-rennes1.fr

b Laboratoire de Synthèse Organique Appliquée, Faculté des Sciences, Université d'Oran 1 Ahmed Ben Bella, BP 1524 El M'Naouer, 31000 Oran, Algeria
E-mail: badri_sofi@yahoo.fr

c UNESCO Chair of Belarusian State University, 14 Leningradskaya Str., Minsk 220030, Belarus
E-mail: hys@tut.by

d Research Institute for Physico-Chemical Problems of Belarusian State University, 14 Leningradskaya Str., Minsk 220030, Belarus

e Centre de Diffractométrie X, Institut des Sciences Chimiques de Rennes, UMR 6226, Université de Rennes 1-CNRS, Bâtiment 10B, Campus de Beaulieu, 35042 Rennes, France

Abstract

The metallation of aryl ketones was achieved by using LiTMP in the presence of ZnCl2·TMEDA, as evidenced by subsequent interception with iodine or by a palladium-catalysed cross-coupling reaction. One of the synthesized iodo ketones has been further elaborated to reach derivatives of biological interest.

Graphical abstract: Functionalization of pyridyl ketones using deprotolithiation-in situ zincation

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Article information

DOI
https://doi.org/10.1039/C6RA11370B
Article type
Communication
Submitted
02 May 2016
Accepted
24 Jun 2016
First published
28 Jun 2016

RSC Adv., 2016,6, 63185-63189

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Functionalization of pyridyl ketones using deprotolithiation-in situ zincation

M. Hedidi, W. Erb, F. Lassagne, Y. S. Halauko, O. A. Ivashkevich, V. E. Matulis, T. Roisnel, G. Bentabed-Ababsa and F. Mongin, RSC Adv., 2016, 6, 63185 DOI: 10.1039/C6RA11370B

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