Issue 63, 2016

Discovery of lipoic acid-4-phenyl-1H-pyrazole hybrids as novel bifunctional ROCK inhibitors with antioxidant activity

Abstract

A series of lipoic acid (LA) and 4-phenyl-1H-pyrazole hybrids as bifunctional Rho-associated kinase (ROCK) inhibitors were designed, synthesized and evaluated. Compound 15 is identified to be a novel potent bifunctional ROCK inhibitor with antioxidant activity and neuroprotection.

Graphical abstract: Discovery of lipoic acid-4-phenyl-1H-pyrazole hybrids as novel bifunctional ROCK inhibitors with antioxidant activity

Supplementary files

Article information

Article type
Communication
Submitted
10 May 2016
Accepted
04 Jun 2016
First published
13 Jun 2016

RSC Adv., 2016,6, 58516-58520

Discovery of lipoic acid-4-phenyl-1H-pyrazole hybrids as novel bifunctional ROCK inhibitors with antioxidant activity

Y. Tu, Q. Chen, S. Wang, A. Uri, X. Yang, J. Chu, J. Chen, B. Luo, X. Chen, S. Wen and R. Pi, RSC Adv., 2016, 6, 58516 DOI: 10.1039/C6RA12081D

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