Synthesis of functionalized tetrahydropyridazines via catalyst-free self [4 + 2] cycloaddition of in situ generated 1,2-diaza-1,3-dienes

Zhimin Zhang; Li Zhang; Qingqing Chen; Tao Lu; Qingfa Zhou

doi:10.1039/C6RA13985J

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Synthesis of functionalized tetrahydropyridazines via catalyst-free self [4 + 2] cycloaddition of in situ generated 1,2-diaza-1,3-dienes†

Zhimin Zhang,^a Li Zhang,^a Qingqing Chen,^a Tao Lu*^a and Qingfa Zhou*^a

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* Corresponding authors

^a State Key Laboratory of Natural Medicines, Department of Organic Chemistry, China Pharmaceutical University, Nanjing, P. R. China
E-mail: zhouqingfa@cpu.edu.cn, lut163@163.com
Fax: +86-025-86285179
Tel: +86-025-86185160

Abstract

An efficient method for the synthesis of structurally diverse functionalized tetrahydropyridazines via self [4 + 2] cycloaddition of in situ generated 1,2-diaza-1,3-dienes was developed, which may play an important role in drug discovery.

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Article information

DOI: https://doi.org/10.1039/C6RA13985J
Article type: Paper
Submitted: 30 May 2016
Accepted: 18 Jun 2016
First published: 21 Jun 2016

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RSC Adv., 2016,6, 61680-61685

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Synthesis of functionalized tetrahydropyridazines via catalyst-free self [4 + 2] cycloaddition of in situ generated 1,2-diaza-1,3-dienes

Z. Zhang, L. Zhang, Q. Chen, T. Lu and Q. Zhou, RSC Adv., 2016, 6, 61680 DOI: 10.1039/C6RA13985J

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