Issue 76, 2016, Issue in Progress

A concise asymmetric total synthesis for structure elucidation of 5,6-secoiridoid from Incarvillea argute

Abstract

A phytochemical investigation of the roots of Incarvillea arguta led to the isolation of secoarguterin (1), which is the first example of 5,6-secoiridoid. Its structure and absolute configuration was elucidated by extensive spectral analysis and total synthesis. Compound 1 showed moderate inhibition against human colon cancer cells HCT116 with an IC50 value of 28.72 μM.

Graphical abstract: A concise asymmetric total synthesis for structure elucidation of 5,6-secoiridoid from Incarvillea argute

Supplementary files

Article information

Article type
Communication
Submitted
11 Jun 2016
Accepted
20 Jul 2016
First published
21 Jul 2016

RSC Adv., 2016,6, 72458-72461

A concise asymmetric total synthesis for structure elucidation of 5,6-secoiridoid from Incarvillea argute

J. Fu, Z. Liu, H. Jin, S. Zhang, Q. Sun and W. Zhang, RSC Adv., 2016, 6, 72458 DOI: 10.1039/C6RA15153A

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