A concise asymmetric total synthesis for structure elucidation of 5,6-secoiridoid from Incarvillea argute†
Abstract
A phytochemical investigation of the roots of Incarvillea arguta led to the isolation of secoarguterin (1), which is the first example of 5,6-secoiridoid. Its structure and absolute configuration was elucidated by extensive spectral analysis and total synthesis. Compound 1 showed moderate inhibition against human colon cancer cells HCT116 with an IC50 value of 28.72 μM.