Issue 76, 2016, Issue in Progress
From the journal:

RSC Advances

An approach to the synthesis of 4-aryl and 5-aryl substituted thiazole-2(3H)-thiones employing flow processing†

Monaem Balti,a   Shelli A. Miller,b   Mohamed Lotfi Efrita  and  Nicholas E. Leadbeater*b  

* Corresponding authors

a Université Tunis El Manar, Laboratory of Organic Synthesis and Heterocyclic Chemistry, Faculty of Science of Tunis, Department of Chemistry, 1060 Tunis, Tunisia

b Department of Chemistry, University of Connecticut, 55 North Eagleville Road, Storrs, CT 06269, USA
E-mail: nicholas.leadbeater@uconn.edu

Abstract

A method for the preparation of 4-aryl and 5-aryl substituted thiazole-2(3H)-thiones is described. Flow processing is employed as a tool, and supported acids and bases used to facilitate both the synthetic strategy and product isolation. The methodology is applicable to a range of substrates.

Graphical abstract: An approach to the synthesis of 4-aryl and 5-aryl substituted thiazole-2(3H)-thiones employing flow processing

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Article information

DOI
https://doi.org/10.1039/C6RA15488C
Article type
Paper
Submitted
14 Jun 2016
Accepted
13 Jul 2016
First published
22 Jul 2016

RSC Adv., 2016,6, 72165-72169

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An approach to the synthesis of 4-aryl and 5-aryl substituted thiazole-2(3H)-thiones employing flow processing

M. Balti, S. A. Miller, M. L. Efrit and N. E. Leadbeater, RSC Adv., 2016, 6, 72165 DOI: 10.1039/C6RA15488C

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