Highly α-regioselective neodymium-mediated allylation of diaryl ketones

Abstract

The first utility of neodymium as a mediating-metal in the highly α-regioselective Barbier reaction of diaryl ketones with allyl halides is reported in this paper. This reaction was conveniently carried out under mild conditions in a one-pot fashion with moderate to good yields. The protocol benefited from an availability of starting material, wide substrate scope, and operational simplicity and constituted a powerful alternative approach.