The first solvent-free synthesis of privileged γ- and δ-lactams via the Castagnoli–Cushman reaction

Abstract

The first solvent-free protocol for the atom-economical Castagnoli–Cushman reaction is reported. It substantially broadens the reaction scope with respect to achievable substitution patterns around the privileged lactam cores compared to the traditional reaction format employing aromatic hydrocarbon solvents. The convenient product isolation protocol involves the use of aqueous base and acid solutions.